Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats

Juvenile play experiences promote behavioral flexibility in rats. If other early positive experiences, such as tactile stimulation, are given prior to exposure to psychostimulants, the behavioral response to the drug is attenuated. The objective of the present study was to determine if the experience of juvenile play behavior would attenuate...

Long-term changes in rat social behavior following treatment with trimethylolpropane

A potent convulsant, trimethylolpropane phosphate (TMPP), was evaluated for long-term effects on measures of social behaviors and anxiety in Long- Evans rats. Animals received three to four daily treatments of TMPP (0.1 mg/kg/ml) beginning at age 23 days in Experiment 1 and 73 days in Experiment 2. Gregariousness was measured...

Sex differences in the effects of haloperidol, morphine, and their combination on colonic temperature in rats

Previously it was found that during the loss of postural support induced by combined administration of haloperidol and morphine, rats became markedly hypothermic. The present work was a more detailed study of this hypothermia. Morphine alone (20 mg/kg) produced a slight hyperthermia (1∞C) in female rats and no effect in...

play fighting between kindling-prone (FAST) and kindling-resistant (SLOW) rats

Differences in the play behavior of 2 strains of rats suggest that different components of play fighting can be modified independently. The development of play fighting in cross-strain pairs of familiar and unfamiliar rats was examined to determine whether interacting with a noncongruent pairmate would alter the pattern of play...

Regulatory mechanisms underlying novelty-induced grooming in the laboratory rat.

Bouts of pelage cleaning can be readily evoked in laboratory rodents under conditions of exposure to novelty. Such novelty-induced grooming is described as stereotyped and rostro-caudal in its progression. The patterned structure of novelty-induced grooming makes it particularly attractive for research on the organizational and motivational underpinnings of co-ordinated behaviour....

Vestibular information is required for dead reckoning in the rat

Dead reckoning is an on-line form of spatial navigation used by an animal to identify its present location and return directly to a starting location, even after circuitous outward trips. At present, it is not known which of several self-movement cues (efferent copy from movement commands, proprioceptive information, sensory flow,...

Tactile Stimulation During Development Attenuates Amphetamine Sensitization and Structurally Reorganizes Prefrontal Cortex and Striatum in a Sex-Dependent Manner

This study investigated the effect of postnatal tactile stimulation (TS) on juvenile behavior, adult amphetamine (AMPH) sensitization, and the interaction of TS and AMPH on prefrontal cortical (PFC) thickness and striatum size. Pups received TS by stroking daily with a feather duster from birth till weaning and were tested, as...

Are 50-khz calls used as play signals in the playful interactions of rats? III. The effects of devocalization on play with unfamiliar partners as juveniles and as adults

When playing, rats emit 50-kHz calls which may function as play signals. A previous study using devocalized rats provides support for the hypothesis that 50-kHz function to promote and maintain playful interactions (Kisko et al., 2015). However, in that study, all pairs were cage mates and familiar with each other's...

Frequency-modulated 50kHz ultrasonic vocalizations: A tool for uncovering the molecular substrates of positive affect

The evidence that frequency modulated (FM) 50 kHz ultrasonic vocalizations (USVs) reflect a positive emotional state in rats is reviewed. Positive emotional states in humans are measured by facial-vocal displays (e.g., Duchenne smiling and laughter), approach behavior, and subjective self-report of feeling states. In laboratory animals, only facial-vocal displays, along...

The archaeology of mind [extracts]

To the best of our knowledge, the basic biological values of all mammalian brains were built upon the same basic plan, laid out in consciousness-creating affective circuits that are concentrated in subcortical regions, far below the neocortical "thinking cap " that is so highly developed in humans. Mental life would...

The role of the striatum in organizing sequences of play fighting in neonatally dopamine-depleted rats

Juvenile rats sustaining dopamine depletions by intraventricular injections of 6-hydroxydopamine (6-OHDA) as neonates were used to study the role of the striatum in controlling play fighting. As juveniles, the rats exhibited all the behavior elements typical of play fighting. However, they were more likely to use defensive tactics that shortened...

Adult-juvenile play fighting in rats: Insight into the experiences that facilitate the development of socio-cognitive skills

Rats reared with playful peers during the juvenile period have a modified prefrontal cortex and improved executive functions, whereas ones reared with less playful partners, such as an adult, do not. It has been hypothesized that peer-peer play fighting creates unique experiences that tax executive functions and so influence the...

Sex differences in play fighting revisited: Traditional and nontraditional mechanisms of sexual differentiation in rats

In the traditional model for sexual differentiation in mammals, the female phenotype is the default condition. That is, the female-typical pattern will persist unless acted upon by hormones early in development. The frequency of play fighting in rats, as in most other mammals, is sexually differentiated, and conforms to the...

Comparative analyses of the role of postnatal development on the expression of play fighting

Whether it is that animals are young so that they can play, or whether it is that they play because they are young, play should be more prevalent in species that have a greater degree of postnatal development. This hypothesis is tested by comparative analyses within two mammalian orders (primates...

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