The neurobiology of RAGE and anger & psychiatric implications with a focus on depression

There has been a perennial debate about whether aggression is learned or innate. The power of extreme arguments in this area has diminished as all are beginning to recognize that both evolution and learning contribute much to our tendency to be aggressive in various distinct ways, including impulsive anger, premeditated predatory behavior in its many forms, as well as our seeking of dominance as exemplified best in inter-male jousting. Here we will be almost exclusively concerned with the biological roots of the type of impulsive aggression that arises from our genetically prescribed capacity for anger, and affective state that we label the RAGE circuitry of the brain. © 2011 Nova Science Publishers, Inc. All rights reserved.