Effects of neonatal handling on play and anxiety in F344 and Lewis rats
Siviy, S.M.
· 1994
★ NIFPlay Rating: 8
Rating Scale
10 Rigorous play-specific science
6–9 General biological science
5 Sound play research (uncontrolled)
1–4 Less rigorous / indirect
0 Indirect but high value
Demonstrates that early neonatal handling experiences permanently alter both play behavior and anxiety responses in adulthood, with effects that vary by genetic strain.
