The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions
Nocjar, C., Zhang, J., Feng, P., J. Panksepp
· 2012
★ NIFPlay Rating: 8
Rating Scale
10 Rigorous play-specific science
6–9 General biological science
5 Sound play research (uncontrolled)
1–4 Less rigorous / indirect
0 Indirect but high value
Demonstrates that social defeat stress depletes orexin in mesocortical dopamine pathways, connecting social play disruption to neurobiological models of depression.
